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The up-and-down sequence of remimazolam dose for inducing loss of responsiveness within two minutes from the start of infusion. The patient sequence number (x-axis) is the ordering of patient exposures. Success: loss of responsiveness within 2 min from the start of remimazolam infusion. Failure: no loss of responsiveness within 2 min from the start of remimazolam infusion. ED50, 50% effective dose; CI, confidence interval.
