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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Centered pooled adjacent violators algorithm (PAVA) response rate. It predicted that an infusion rate of 0.10 mg/kg/min could induce loss of responsiveness within two minutes from the start of infusion in 90% of patients.