Table 3.
Hemodynamic changes and secondary outcomes between the groups.
| Variables | Success Group (n = 11) |
Failure Group (n = 9) |
p-Value a |
|---|---|---|---|
| Time interval from the start of infusion to loss of responsiveness, sec | 95 [77–100] | NA | |
| Total amount of remimazolam, mg | 13 [10–13] | NA | |
| Patients who needed vasoactive medication during induction |
0 | 0 | |
| During the induction of anesthesia | |||
| Mean blood pressure, mmHg | 0.533 | ||
| Before induction of anesthesia | 97 [85–107] | 91 [86–104] | |
| At the loss of responsiveness | 87 [80–100] | 77 [68–99] | |
| After 1 min after intubation | 117 [93–129] | 96 [78–124] | |
| After 3 min after intubation | 105 [90–112] | 87 [83–124] | |
| After 5 min after intubation | 98 [88–106] | 94 [85–100] | |
| Heart rate, beats/min | 0.581 | ||
| Before induction of anesthesia | 74 [66–78] | 76 [68–87] | |
| At the loss of responsiveness | 76 [63–95] | 80 [77–91] | |
| After 1 min after intubation | 94 [82–96] | 104 [92–108] | |
| After 3 min after intubation | 90 [86–101] | 94 [93–111] | |
| After 5 min after intubation | 96 [85–105] | 82 [84–100] | |
| Bispectral index | 0.428 | ||
| Before induction of anesthesia | 93 [89–97] | 94 [91–97] | |
| At the loss of responsiveness | 56 [48–69] | 57 [41–66] | |
| After 1 min after intubation | 57 [40–61] | 45 [30–59] | |
| After 3 min after intubation | 48 [36–59] | 39 [29–59] | |
| After 5 min after intubation | 40 [39–53] | 50 [28–55] | |
| Patients who experienced intraoperative awareness | 0 | 0 |
Data presented as median [interquartile range] or number (%). a p-value was calculated using the repeated measures analysis of variance (ANOVA).