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. 2023 Feb 23;24(5):4437. doi: 10.3390/ijms24054437

Figure 2.

Figure 2

Characterization of DA neurons and their precursors. (a) qPCR gene expression analysis of DA neuron markers (TH, LMX1A, and NURR1) in neurons at days 50–60 of differentiation (blue) compared to iPSCs (gray) (n = 3); (b) flow cytometry analysis of the DA neuron precursor cells at day 34 of differentiation for early marker (LMX1A) and specific neuroectodermal markers (SOX1 and OTX2), n = 4; (c) expression level of GBA in DA neurons obtained from two GBA mutation carriers (GBA-PD and GBA-carrier) and “healthy” controls before (blue) and after (red) ambroxol (ABX) treatment.