Table 1.
Activities of the lysosomal enzymes are presented as medians (min–max).
| Lysosomal Enzyme | GBA-PD (N370S/WT) | GBA-Carrier (N370S/WT) | Controls |
|---|---|---|---|
| GCase, nM/mg of protein/h | 5.8 (4.8–6.9) * p < 0.0001 # p = 0.025 |
6.6 (5.5–7.9) * p = 0.018 |
7.6 (6.5–10.1) |
| GALC, nM/mg of protein/h | 8.5 (7.3–10.6) # p = 0.045 |
10.6 (6.4–16.3) | 8.4 (6.6–13.1) |
| GAA, nM/mg of protein/h | 17.2 (12.4–20.3) | 17.6 (14.8–19.3) | 16.5 (8.8–18.6) |
| GLA, nM/mg of protein/h | 12.2 (8.9–14.6) * p = 0.008 # p = 0.002 |
9.6 (7.6–10.5) | 9.8 (8.8–12.1) |
| ASM, nM/mg of protein/h | 9.5 (6.9–11.1) | 9.9 (8.8–11.9) | 8.9 (7.8–11.8) |
| IDUA, nM/mg of protein/h | 20.9 (18.2–23.1) * p < 0.0001 # p < 0.0001 |
12.1 (8.4–16.9) | 10.9 (6.9–20.9) |
* Compared to controls, # Compared to GBA-carrier.