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. 2023 Mar 2;24(5):4866. doi: 10.3390/ijms24054866

Table 5.

Agreement between p53 IHC and TP53 NGS.

TP53 NGS
All EC (n = 104) POLEwt and MMRp EC (n = 48)
Mutated Normal Mutated Normal
p53 IHC Abnormal 18 12 12 8
Normal 6 68 1 27
Sensitivity % 75.0
(95% CI: 53.3–90.2) *
92.3
(95% CI: 64.0–1.00) *
Specificity % 85.0
(95% CI: 75.3–92.0) *
77.1
(95% CI: 59.9–89.6) *
Accuracy % 82.7
(95% CI: 74.0–89.4) *
81.3
(95% CI: 67.4–91.1) *
PPV % 60.0
(95% CI: 41.6–77.3) *
60.0
(95% CI: 36.1–80.9) *
NPV % 92.0
(95% CI: 83.2–97.0) *
96.4
(95% CI: 81.7–99.9) *

* Exact Cis.