Table 5.
TP53 NGS | |||||
---|---|---|---|---|---|
All EC (n = 104) | POLEwt and MMRp EC (n = 48) | ||||
Mutated | Normal | Mutated | Normal | ||
p53 IHC | Abnormal | 18 | 12 | 12 | 8 |
Normal | 6 | 68 | 1 | 27 | |
Sensitivity % | 75.0 (95% CI: 53.3–90.2) * |
92.3 (95% CI: 64.0–1.00) * |
|||
Specificity % | 85.0 (95% CI: 75.3–92.0) * |
77.1 (95% CI: 59.9–89.6) * |
|||
Accuracy % | 82.7 (95% CI: 74.0–89.4) * |
81.3 (95% CI: 67.4–91.1) * |
|||
PPV % | 60.0 (95% CI: 41.6–77.3) * |
60.0 (95% CI: 36.1–80.9) * |
|||
NPV % | 92.0 (95% CI: 83.2–97.0) * |
96.4 (95% CI: 81.7–99.9) * |
* Exact Cis.