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. 2023 Feb 28;24(5):4668. doi: 10.3390/ijms24054668

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chemokine expression is increased in bleomycin-treated skin from MKP-1-deficient mice. MCP-1 (A), MIP-1α (B), and MIP-2 (C) mRNA expression in untreated control skin and in the skin treated with bleomycin from wild-type (WT) and MKP-1-deficient (MKP-1^−/−) mice was measured by quantitative RT-PCR analysis and normalized against GAPDH mRNA. MCP-1, MIP-1α and MIP-2 levels in WT control skin was set as 1, and the other values are given in relation to that value. Bars represent mean + SEM; n = 8 in the control groups and n = 6 in the bleomycin groups. Statistical significance of the results was calculated by two-way ANOVA followed by Tukey’s multiple comparisons test.