Table 2.
Characteristics of included clinical studies related to the relationship between LDL-C and AP.
| Author and Year of Publication | Type of Study | Sample Size | Lipids | Result/Conclusion |
|---|---|---|---|---|
| Hong et.al, 2022 [91] | Retrospective study | Non-SAP patient (n = 438) and SAP patient (n = 49) | HDL-C, LDL-C | Based on a variable importance analysis of the RF model, LDL-C is an important predictor of SAP. |
| Liao et.al, 2021 [99] | Retrospective study | hypertriglyceridemic pancreatitis patients (n = 157) | Triglyceride, LDL-C | Higher LDL-C was associated with HTGP recurrence. |
| Wu et. al, 2019 [101] | Retrospective study | Non-SAP patient (n = 310) and SAP patient (n = 65) | Serum Apo B/A1 ratio | Apo B is the main structure of LDL-C. The serum Apo B/A1 ratio at admission is closely correlated with disease severity in patients with AP and can serve as a reliable indicator for SAP in the clinical setting. |
| Hong et. al, 2018 [13] | Retrospective study | AP patient (n = 647) | HDL-C, LDL-C | LDL-C (90 mg/dL) levels within 24 h of admission are independently associated with an increased risk of SAP. |
| Hong et.al, 2017 [100] | Case-control study | AP patients with amylase ≥300 U/L (n = 108) and AP patients with amylase <300 U/L (n = 108). | LDL-C, triglyceride | Higher LDL-C levels are independently associated with the development of AP along with low serum amylase. |
| Peng et.al, 2015 [97] | Prospective study | patients predicted SAP (n = 66) | Total cholesterol, HDL-C, LDL-C, triglyceride | The serum LDL-C level of patients with persistent organ failure was significantly lower than that of patients without persistent organ failure within 24 h of admission, and persistent organ failure is closely related to the high mortality rate of SAP. |
| Khan et. al, 2013 [96] | Retrospective study | Non-SAP patient (n = 30) and SAP patient (n = 203) | Serum total cholesterol, HDL-C, LDL-C | The level of LDL-C is significantly lower in patients with SAP and is associated with longer hospitalization. |
Abbreviations: AP, acute pancreatitis; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SAP, severe acute pancreatitis; Apo B, apolipoprotein B; Apo A1, apolipoprotein A1.