Table 1.

Advantages and limitations of renal radiogenomics.

Radiogenomics	Advantages	Limitations
	Improvement in screening and management of at-risk individuals [78,79,80,81,82]	Many retrospective studies [203,204]
	Assessment of whole tumor molecular pattern [203]	No standardization of protocols [199,203,204,234]
	Increasing use of artificial intelligence in statistical models [206,226]	Lack of proper clinical trials [215]
	Prediction of overall survival and metastasis [211,212,213,218,219,220,221,222,223,224,225]	Lack of multivariate models of mutation status [214]
	Possibility to tailor treatment according to genomic expressions [230,231]	Inter-observer variability [8]
	Genetic and epigenetic profiling of scanned lesions [203]	Automatic extraction of features still underpowered [235]
	Preoperative identification of benign lesions [238]	High cost of genomic testing to validate data [236]