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(A) Crystal structure of SARS-CoV-2 Mpro (PDB ID: 6Y2E): the first protomer is colored in salmon, while the second protomer is colored in pink, and the active site position is highlighted with a blue circle. (B) Close-up view of the catalytic site: the H41-C145 dyad is highlighted, alongside the conserved water molecule that substitutes the third member of the canonical catalytic triad diffused in several cysteine proteases.
