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. 2023 Mar 5;24(5):4988. doi: 10.3390/ijms24054988

Figure 2.

Figure 2

(A,B) Resveratrol’s colony formation and migration inhibition as well as chemosensitisation to 5-FU via β1-integrin receptors in HCT-116/HCT-116R cells. HCT-116 (A) and HCT-116R (B) cells in alginate matrix maintained untreated as basal control (Ba.Co.), as TME control or TME-CRC cells were treated with 5-FU (1, 2 nM), resveratrol (1, 5 µM), β1-SO (0.5 µM), β1-ASO (0.5 µM) alone or in combination. CRC-alginate drops were photographed ((A,B), upper row each) and formed colonies were marked with black arrows. Migrated and settled CRC cell colonies were stained with toluidine blue ((A,B), lower row each). Statistical evaluation: p < 0.05 (⋆) and p < 0.01 (⋆⋆), related to TME control. White bars show the colonosphere formed in alginate drops and black bars show the bottom-settled CRC cell colonies.