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. 2023 Mar 5;24(5):4988. doi: 10.3390/ijms24054988

Figure 3.

Figure 3

Figure 3

(A,B) Resveratrol’s phenotype change, apoptosis induction and chemosensitisation to 5-FU via β1-integrin receptors in HCT-116/HCT-116R cells shown by transmission electron microscopy. HCT-116 (A(a–d),B(a–d)) and HCT-116R (A(e–h),B(e–h)) in monolayer cultures were cultivated as untreated basal control (Ba.Co.), untreated TME control (TME) or CRC cells in TME were treated with 2 nM 5-FU or 5 µM resveratrol alone or combined with 0.5 µM β1-SO or 0.5 µM β1-ASO and ultrastructural were investigated. Star: apoptosis, arrow: mesenchymal cell extensions, arrowhead: smooth epithelial cell surface. Scale bar 1 µm. (C) The statistic diagram illustrates mitochondrial changes (MC) and apoptosis (%) in HCT-116 (black bars) and HCT-116R (white bars) CRC cells with p < 0.05 (⋆) and p < 0.01 (⋆⋆), compared to TME control.