Table 2.
Analysis of miRNA polymorphisms for neurological toxicity.
| ID SNV | Neurological Toxicity | p-Value a | OR (CI 95%) b | |
|---|---|---|---|---|
| Yes | No | |||
| MIR149_rs2292832 | ||||
| CC | 0 (0.0) | 1 (2.4) | 0.016 | TT vs. others |
| CT | 2 (14.3) | 22 (52.4) | ||
| TT | 12 (85.7) | 19 (45.2) | 7.26 (1.44–36.54) | |
| Allele C | 2 (7.1) | 24 (28.6) | ||
| Allele T | 26 (92.9) | 60 (71.4) | ||
| MIR605_rs2043556 | ||||
| CC | 0 (0.0) | 8 (25.0) | 0.039 | TT vs. others |
| CT | 1 (12.5) | 11 (34.4) | ||
| TT | 7 (87.5) | 13 (40.6) | 10.23 (1.12–93.34) | |
| Allele C | 1 (6.2) | 27 (42.2) | ||
| Allele T | 15 (93.8) | 37 (57.8) | ||
| MIR938_rs2505901 | ||||
| CC | 4 (26.7) | 7 (16.7) | 0.030 | TT vs. others |
| CT | 10 (66.7) | 17 (40.5) | ||
| TT | 1 (6.7) | 18 (42.9) | 0.09 (0.01–0.79) | |
| Allele C | 18 (60.0) | 31 (36.9) | ||
| Allele T | 12 (40.0) | 53 (63.1) | ||
| MIR2053_rs10505168 | ||||
| CC | 0 (0.0) | 4 (21.1) | 0.025 | TT vs. others |
| CT | 4 (28.6) | 2 (10.5) | ||
| TT | 10 (71.4) | 13 (68.4) | 4.61 (1.21–17.65) | |
| Allele C | 4 (14.3) | 28 (37.8) | ||
| Allele T | 24 (85.7) | 46 (62.2) | ||
ap-value < 0.05; b simple logistic regression.