Table 3.
Analysis of miRNA polymorphisms for gastrointestinal toxicity.
| ID SNV | Gastrointestinal Toxicity | p-Value a | OR (CI 95%) b | |
|---|---|---|---|---|
| Yes | No | |||
| MIR938_rs2505901 | ||||
| CC | 5 (13.2) | 6 (30.0) | 0.045 | CC vs. others |
| CT | 24 (63.2) | 4 (20.0) | ||
| TT | 9 (23.7) | 10 (50.0) | 0.20 (0.04–0.96) | |
| Allele C | 34 (44.7) | 16 (40.0) | ||
| Allele T | 42 (55.3) | 24 (60.0) | ||
| DROSHA_rs639174 | ||||
| CC | 13 (72.2) | 2 (25.0) | 0.040 | CC vs. others |
| CT | 5 (27.8) | 5 (62.5) | ||
| TT | 0 (0.0) | 1 (12.5) | 11.63 (1.11–121.55) | |
| Allele C | 31 (86.1) | 9 (56.3) | ||
| Allele T | 5 (13.9) | 7 (43.8) | ||
| MIR323B_rs56103835 | ||||
| CC | 3 (8.6) | 0 (0.0) | 0.045 | TT vs. others |
| CT | 21 (60.0) | 6 (37.5) | ||
| TT | 11 (31.4) | 10 (62.5) | 0.23 (0.05–0.96) | |
| Allele C | 27 (38.6) | 6 (18.3) | ||
| Allele T | 43 (61.4) | 26 (81.3) | ||
ap-value < 0.05; b Logistic regression adjusted for African ancestry.