Table 3.
Species-dependent functional actions of dopamine via dopamine receptors on myocardial tissue. Here, the meagre evidence is assembled where dopamine not exclusively but measurably exerts functional cardiac effects via dopamine receptors. Abbreviations: LTCC: L-type calcium ion current. Moreover, we mention which agonist or antagonist for dopamine receptors was used to reach a conclusion. Please see Table 1A,B for the appropriateness of the drugs used in these studies.
| Tissue/Species | LTCC | Agonist | Antagonist | Force | |
|---|---|---|---|---|---|
| Neonatal rabbit cardiomyocyte | Large increase | SKF-38393, dopamine |
SCH-39390 | n.d. | Ding et al., 2008 [2] |
| Adult rabbit cardiomyocyte |
Small increase | SKF-38393, dopamine |
SCH-39390 | n.d. | Ding et al., 2008 [2] |
| Isolated heart from monocrotaline- treated rat |
n.d. | dopamine | SCH-39390 | small increase | Piao et al., 2012 [63] |