Table I.

List of common regulatory single nucleotide polymorphisms and their target regulatory genes shared by both discovery and replication studies.

Gene	Discovery				Replication		Regulatory elements
	GWAS-rSNPs	EAF	Beta	pdiscovery	GWAS-rSNPs	preplication
FAM3C	rs7776725	0.259	0.186	1.21 × 10-25	rs7776725	1.80 × 10-12	CIRs TADs
PTPRZ1	rs7776725	0.259	0.186	1.21 × 10-25	rs7776725	1.80 × 10-12	CIRs TADs
CCDC122	rs9533094	0.404	-0.083	2.80 × 10-20	rs150081494	1.05 × 10-15	TADs
DCLK1	rs9533094	0.404	-0.083	2.80 × 10-20	rs191115702	1.52 × 10-16	TADs
TPTE2P5	rs9594738	0.403	-0.082	3.63 × 10-20	rs150081494	1.05 × 10-15	TADs
ENSG00000253603	rs7006553	0.385	0.078	9.99 × 10-18	rs140103265	1.80 × 10-12	CIRs
C11orf58	rs16931831	0.195	0.080	4.41 × 10-15	rs138547759	6.57 × 10-14	TADs
SOX6	rs16931831	0.195	0.080	4.41 × 10-15	rs138547759	6.57 × 10-14	TADs
ULK4	rs369145	0.451	-0.057	1.57 × 10-13	rs117982632	2.26 × 10-9	CIRs
	rs10896328	0.238	-0.081	2.09 × 10-13	rs117982632	2.26 × 10-9	TADs
PPP6R3	rs12272917	0.237	-0.074	4.58 × 10-13	rs17149179	3.14 × 10-10	CIRs
	rs12274114	0.255	-0.072	1.17 × 10-12	rs67446678	2.32 × 10-9	TFBRs
	rs10896328	0.238	-0.081	2.09 × 10-13	rs72936524	5.15 × 10-10	TADs
CHKA	rs12272917	0.237	-0.074	4.58 × 10-13	rs2186937	6.70 × 10-10	CIRs
CTTN	rs4084149	0.237	-0.075	3.43 × 10-13	rs374538301	1.16 × 10-11	TADs
ELMO1	rs1357651	0.355	-0.068	3.75 × 10-13	rs147344245	2.23 × 10-14	TADs
AMPH	rs1357651	0.355	-0.068	3.75 × 10-13	rs147344245	2.23 × 10-14	TADs
NDUFA3P2	rs12272917	0.237	-0.074	4.58 × 10-13	rs2186937	6.70 × 10-10	CIRs TADs
ENSG00000234985	rs7776725	0.259	0.072	6.85 × 10-13	rs7776725	1.80 × 10-12	CIRs TADs
GEMIN6	rs73215359	0.080	0.183	4.77 × 10-12	rs114805039	5.80 × 10-11	CIRs TFBRs
ADGB	rs7740522	0.505	-0.053	1.23 × 10-11	rs115947573	9.21 × 10-24	TADs
SYNE1	rs7740522	0.505	-0.053	1.23 × 10-11	rs115947573	9.21 × 10-24	TADs
PLEKHG1	rs7740522	0.505	-0.053	1.23 × 10-11	rs145135839	4.74 × 10-17	TADs
CCDC170	rs7740522	0.505	-0.053	1.23 × 10-11	rs182402542	3.22 × 10-9	TADs
CBX5	rs3803042	0.417	-0.061	3.23 × 10-11	rs57292110	7.11 × 10-16	CIRs TFBRs
COG6	rs9533110	0.496	0.055	9.83 × 10-10	rs116613004	1.38 × 10-11	TADs
EPSTI1	rs9533110	0.496	0.055	9.83 × 10-10	rs554647317	4.39 × 10-8	TADs
ENSG00000254789	rs12797380	0.477	0.047	2.05 × 10-9	rs539468022	1.63 × 10-10	TADs
PSMA1	rs12797380	0.477	0.047	2.05 × 10-9	rs539468022	1.63 × 10-10	TADs
SUV420H1	rs7935347	0.153	-0.075	3.08 × 10-9	rs183720308	1.03 × 10-10	CIRs
RNU2-63P	rs4528686	0.362	0.071	6.58 × 10-9	rs116151937	5.28 × 10-14	CIRs TFBRs
EPDR1	rs1376264	0.271	0.055	9.30 × 10-9	rs147344245	2.23 × 10-14	TADs
ANLN	rs1376264	0.271	0.055	9.30 × 10-9	rs138651438	6.42 × 10-10	TADs
OTOG	rs11024028	0.147	0.066	1.44 × 10-8	rs372278011	1.02 × 10-14	TADs
ENSG00000246225	rs11024028	0.147	0.066	1.44 × 10-8	rs77490678	3.00 × 10-16	TADs
USAH1C	rs11024028	0.147	0.066	1.44 × 10-8	rs138547759	6.57 × 10-14	TADs
BDNF-AS	rs11024028	0.147	0.066	1.44 × 10-8	rs187573374	3.33 × 10-17	TADs
PLEKHM1	rs34814687	0.053	0.085	1.75 × 10-8	rs144518135	1.56 × 10-15	TADs
CSAD	rs4759021	0.248	0.053	4.04 × 10-8	rs556893559	8.42 × 10-12	CIRs

p_discovery denotes the p-value of discovery GWAS-rSNPs; p_replication denotes the p-value of replication GWAS-rSNPs.

CIRs, chromatin interactive regions; EAF, effect allele frequency; GWAS, genome-wide association study; rSNP, regulatory single nucleotide polymorphism; TADs, topologically associated domains; TFBRs, transcription factor binding regions.