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. 2023 Mar 3;24(5):4920. doi: 10.3390/ijms24054920

Figure 1.

Figure 1

Comparison of tissue penetrance relative to dose of X-rays, PBT and CIRT. (A) Tissue-depth-relative dose distribution of X-rays, and pristine proton and carbon ion beams, along with the variation of dose averaged LET for protons varying from ~1 keV/μm to ~17 keV/μm (the LET of carbon ions follows a similar trend, reaching a maximum of ~300–400 keV/μm). (B) The use of multiple pristine proton beams of different energies to give a produce a SOBP that generates a relatively uniform dose distribution across a tumour volume. (C) The use of multiple carbon ion beams to produce a SOBP, but taking into account the calculated RBE and varying the physical dose to give a relatively uniform biological dose across the tumour.