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. 2023 Mar 1;24(5):4756. doi: 10.3390/ijms24054756

Figure 7.

Figure 7

miR-199a-5p inhibits OSCC cell migration and invasion through the downregulation of SMARCA4. (A–D) The effect of SMARCA4 overexpression on miR-199a-5p mimics-induced OSCC cell migration and invasion inhibition. SAS cells were transfected with miR-199a-5p mimics, or miR-199a-5p mimics and SMARCA4 overexpression plasmid. Cell migration was measured by both the wound healing assay (A) and Transwell migration assay (C), and cell invasion was measured by the Transwell invasion assay (C). Quantitative analysis was performed by the Image J software (B,D). (E–H) The effect of SMARCA4 inhibition on miR-199a-5p inhibitor-induced OSCC cell migration and invasion. SAS cells were transfected with miR-199a-5p inhibitor, or miR-199a-5p inhibitor and sh-SMARCA4. Cell migration was measured by both the wound healing assay (E) and Transwell migration assay (G), and cell invasion was measured by the Transwell invasion assay (G). Quantitative analysis was performed by the Image J software (F,H). The scale bar is shown in lower-right corner. Data are expressed as the mean ± SEM from triplicate experiments. ** p < 0.01, *** p < 0.001, **** p < 0.0001, comparison with the corresponding controls.