Figure 8.

Knockdown of SMARCA4 suppresses OSCC tumorigenesis associated with upregulated miR199-a-5p in vivo. (A) Xenograft nude mice were injected with SAS cells stably transfected with sh-SMARCA4 or sh-NC. After 2 weeks, the mice were sacrificed, and the tumors were collected. The tumor size was measured using a caliper. (n = 5, each group). (B) Comparison of tumor growth rate between the sh-SMARCA4 group and sh-NC group. (C) Comparison of tumor weight between the sh-SMARCA4 group and sh-NC group. (D) Representative IHC staining images of SMARCA4, E-cadherin, and vimentin protein in tumor tissues from the sh-SMARCA4group or sh-NC group (scare bars: 10$\times$: 100 µm, 40$\times$: 20 µm). (E) Comparison of SMARCA4 or miR199-a-5p mRNA expression levels in tumor tissues from the sh-SMARCA4 group and sh-NC group. * p < 0.05, *** p < 0.001, **** p < 0.0001, comparison with the sh-NC group.