Figure 3.

Potential mitochondria targeting strategies in prostate cancer. (a) Citrate oxidation is important for transformation of PCa cells, and blocking it could be a first step in treatment of PCa. (b) High lactate levels promote interaction between mitochondria and cancer-associated fibroblasts, and thus blocking this interaction would seem to be a viable therapeutic strategy. (c) Reducing mitochondrial levels of oncometabolites by altering mitochondrial transporters and (d) regulating mitochondrial dynamics via MFN2, DRP-1, and MIRO2 could also provide an effective treatment option for PCa. Figure was created with BioRender.com (accessed on 15 February 2023).