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Potential zymosan and empagliflozin interactions with TLR2. (A) Zymosan may interact via multiple hydrogen bonds (dotted yellow lines) with R423, V425, D444, S445, and S447 amino acid residues of TLR-2. (B) Empagliflozin has a moiety identical to Zymosan. (C) The zymosan-like moiety may enable Empagliflozin to interact withV425 and S445 amino acid residues of TLR-2 via H-bond formation.
