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Metformin and empagliflozin as single agents or in combination have contrasting effects on inflammatory gene expression in BMDM compared to single agents. (A,B) 2 h, 10 μM, (C,D) 24 h, 10 μM (Met = Metformin, Empag = Empagliflozin, M+E = combination, n = 3–4 per group, one-way ANOVA, data are mean ± SEM, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 relative to control, ns; not significant).
