Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 5;24(5):4996. doi: 10.3390/ijms24054996

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

SPRED2 expression in HCC tissues. (A) Among 371 HCC cases from TCGA database, 82 cases that could be followed for 2 years, including those who died, were selected. The SPRED2 expression of these 82 cases was dichotomized, and a survival curve was drawn with the high 50% as SPRED2-high and the low 50% as SPRED2-low. (B–E) Data from our 40 HCC patients. (B) The expression levels of SPRED2 mRNA. (C) Representative photos of SPRED2 immunohistochemistry from well and poorly differentiated HCC tissues. Scale bars: 50 μm. (D,E) Expressions of pluripotency factors in HCC tissues. mRNA was extracted from paraffin block. (D) The expression levels of Nanog, c-Myc and KLF4 were measured by RT-qPCR. (E) The relation between Nanog/c-Myc/Klf4 and SPRED2 was analyzed. ^# p < 0.05, ^§ p < 0.01, ^¶ p < 0.001, two-tailed unpaired t test.