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DPSC-Exos local injection effectively relieved bone destruction in progressive knee OA. (A) Timeline of induction and treatment of mice knee OA. (B) Representative coronal and sagittal view and three-dimensional reconstruction of the knees in the different groups by micro-CT. Yellow arrows: sclerosis or osteophytes. (C) Statistical analysis of bone deterioration-relative parameters. Data are presented by mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001; n = 5.
