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. 2023 Mar 3;24(5):4926. doi: 10.3390/ijms24054926

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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DPSC-Exos local injection improved cartilage degradation and synovial inflammation in progressive knee OA. (A) Representative images of HE and Safranin-O staining of the mice knee. The results of Mankin scoring system showed significant difference between OA-PBS and OA-Exo groups. (B) Representative images and semi-quantitative analysis of collagen II (COL2) in femoral and tibial cartilage by IHC staining. (C) Representative images and semi-quantitative analysis of IL-1β and TNF-α in synovium by IHC staining. The data of semi-quantitative analysis were presented by mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001; n = 5.