A prognostic model derived from the Stem. Sig. by an integrated machine-learning framework. (a) A total of 101 combinations of machine learning algorithms via a 10-fold cross-validation framework. The C-index of each model was calculated across validation datasets, including TCGA-BLCA, GSE13507, GSE31684, GSE32548, and GSE32894 datasets. (b) The importance of the 17 most valuable genes based on the RSF algorithm. Kaplan-Meier survival curve of OS between patients with a high score and with a low score in the TCGA-BLCA (c), GSE13507 (d), GSE31684 (e), GSE32548 (f), and GSE32894 (g) datasets.