Table 2.
Summary of the protective effects of baicalein in various experimental models.
| Experimental Model | Mechanism of Action | Effect | Ref. |
|---|---|---|---|
| Mouse | Promoted pancreatic β-cell insulin secretory function | Antidiabetic | [100] |
| Rat pulmonary fibrosis model | Repressed miR-21 expression | Antifibrotic | [101] |
| Cell culture of HMC-1 cells | Inhibited IL-6, IL-8, and MCP-1 production | Anti-inflammatory | [106] |
| Mouse | Decreased level of serum IgE, mMCP-1, Th-1, and Th-17 | Antiallergic | [109] |
| Sodium-induced mouse colitis | Attenuated activity and phosphorylation of IKKβ | Anticancer | [110] |
| Culture of THP-1 macrophages | Inhibited intracellular cholesterol accumulation | Anti-atherosclerosis | [117] |
| LPS-induced rats septic shock | Ameliorated increase in hepatic TNF-a, and inhibited iNOS protein expression |
Protective effect against endotoxemia | [119] |