Table 5.
Top 10 canonical pathways and related proteins in diabetes compared with wild-type mice.
| Canonical Pathway | Log (p Value) |
Ratio | Z-Score | Proteins |
|---|---|---|---|---|
| Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 2.45 | 0.0321 | 2 | C1QA, C1QB, C1QC, MBL2, TGFB1 |
| Apelin Cardiomyocyte Signaling Pathway | 2.40 | 0.0404 | 2 | GNAI2, MYL6, MYL9, TGFB1 |
| White Adipose Tissue Browning Pathway | 1.90 | 0.029 | 2 | CAMP, LDHA, LDHB, THRB |
| SNARE Signaling Pathway | 4.51 | 0.0515 | 1.89 | MYH10, MYH14, MYH9, MYL6, MYL9, RAB6A, RAB7A |
| Complement System | 8.43 | 0.189 | 1.89 | C1QA, C1QB, C1QC, C4BPA, MASP1, MASP2, MBL2 |
| PPARα/RXRα Activation | 3.53 | 0.0359 | 1.633 | ACADL, APOA1, APOA2, GNAQ, RAP1A, RAP1B, TGFB1 |
| IL-8 Signaling | 9.97 | 0.0667 | 1.508 | CDC42, EGFR, GNA13, GNAI2, GNAQ, GNAZ, RAC1, RAC2, RAP1A, RAP1B, RHOA, VCAM1 |
| NAD Signaling Pathway | 2.51 | 0.0331 | 1.342 | ACADL, ACADM, LDHA, LDHB, TGFB1 |
| CLEAR Signaling Pathway | 1.41 | 0.0175 | 1.342 | EGFR, RAB7A, RAP1A, RAP1B, TGFB1 |
| Apelin Adipocyte Signaling Pathway | 5.66 | 0.0769 | 1.342 | GNAI2, GPX1, GPX3, GSTM1, RAC1, RAC2, SOD1 |
Ratio refers to the number of proteins from the dataset that map to the pathway listed divided by the total number of proteins that map to the canonical pathway from within the IPA knowledgebase.