Table 6.
Top 10 canonical pathways and related proteins in hypertension compared with wild-type mice.
| Canonical Pathway | Log (p Value) |
Ratio | Z-Score | Proteins |
|---|---|---|---|---|
| Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 2.39 | 0.0321 | 2 | C1QA, C1QB, C1QC, MBL2, TGFB1 |
|
White Adipose Tissue Browning
Pathway |
1.85 | 0.029 | 2 | CAMP, LDHA, LDHB, THRB |
|
Semaphorin Neuronal Repulsive
Signaling Pathway |
1.72 | 0.0265 | 2 | MYL6, MYL9, RAC1, RHOA |
| RHOA Signaling | 4.68 | 0.0565 | 1.89 | ARPC2, ARPC4, ARPC5, GNA13, MYL6, MYL9, RHOA |
| Regulation of Actin-based Motility by Rho | 7.04 | 0.0776 | 1.667 | ARPC2, ARPC4, ARPC5, CDC42, MYL6, MYL9, RAC1, RAC2, RHOA |
| Phagosome Formation | 8.09 | 0.0304 | 1.606 | ARPC2, ARPC4, ARPC5, CDC42, IGHE, IGHG3, IGHM, IGKC, LCAT, MYH10, MYH11, MYH14, MYH9, MYL6, MYL9, RAC1, RAC2, RAP1A, RAP1B, RHOA, TLN1 |
| IL-8 Signaling | 9.79 | 0.0667 | 1.508 | CDC42, EGFR, GNA13, GNAI2, GNAQ, GNAZ, MMP2, MYL9, RAC1, RAC2, RAP1A, RAP1B, RHOA, VCAM1 |
| ILK Signaling | 8.99 | 0.065 | 1.508 | CDC42, FLNA, ILK, MYH10, MYH11, MYH14, MYH9, MYL6, MYL9, PARVB, RAC1, RAC2, RHOA |
| Signaling by Rho Family GTPases | 7.46 | 0.0485 | 1.414 | ARPC2, ARPC4, ARPC5, CDC42, GNA13, GNAI2, GNAQ, GNAZ, MYL6, MYL9, RAC1, RAC2, RHOA |
| Actin Cytoskeleton Signaling | 14.30 | 0.0776 | 1.213 | ARPC2, ARPC4, ARPC5, CDC42, FLNA, GNA13, KNG1, MYH10, MYH11, MYH14, MYH9, MYL6, MYL9, RAC1, RAC2, RAP1A, RAP1B, RHOA, TLN1 |
Ratio refers to the number of proteins from the dataset that map to the pathway listed divided by the total number of proteins that map to the canonical pathway from within the IPA knowledgebase.