Figure 2.

Protective effects of isocorydine on LPS-induced acute lung injury in mice. Body weight (A) and food intake (B) were monitored for 21 days in mice intraperitoneally injected with different doses of ICD and DEX (5 mg/kg). LPS-induced acute lung injury mouse model was established. (C) H&E staining of lung tissues. Scale bars, 200 μm. (D) Inflammation score of lungs. (E) Lung wet/dry weight ratios. (F) Statistics of survival time in ICD and control groups after LPS treatment. The mean and SD of at least three independent experiments are shown. * p < 0.05, ** p < 0.01 indicate significant differences between groups as determined by a two-tailed paired Student’s t-test.