Table 3.

Up to 2-year median change in the RHS and HFMSE cross-tabulated by SMA type and age. N: number of participants, M: number of assessments, IQR: inter-quartile range.

Age		<5				5–7				8–13				14–18
SMA Type		6 m	12 m	18 m	24 m	6 m	12 m	18 m	24 m	6 m	12 m	18 m	2 4 m	6 m	12 m	18 m	24 m
2	M	89	67	29	22	39	24	12	11	51	46	30	24	9	7	4	1
	N	37	28	19	12	20	15	8	7	27	23	15	16	5	6	3	1
	RHS Median (IQR)	0 (0, 2)	1 (0, 2)	2 (0, 5)	1 (1, 4.5)	0 (−1, 0)	−0.5 (−2, 0.25)	−2 (−4, 0)	−2 (−4, −1)	0 (−1, 1)	−1 (−2, 0)	−1 (−3.75, 0)	−1.5 (−4.25, 0)	0 (−1, 1)	0 (−1, 0)	0 (0, 0)
	p-value	0.01	<0.001	0.002	0.003	0.405	0.238	0.18	0.021	0.487	0.003	0.023	0.019
	HFMSE Median (IQR)	0 (0, 2)	1 (0, 4)	2 (0, 5)	2 (1, 5.75)	0 (−2, 1)	−1 (−3.25, 0.25)	−2 (−5, 0.25)	−4 (−4.5, −2)	0 (−2, 0)	−1 (−3.75, 0)	−4 (−6, 0)	−3 (−8, 0)	0 (0, 0)	0 (−0.5, 0)	−0.5 (−1, 0)
	p-value	0.006	0.002	0.015	0.001	0.442	0.052	0.344	0.065	0.024	<0.001	<0.001	0.004
3a	M	10	13	10	7	26	22	12	11	58	44	28	15	8	6	2	0
	N	6	9	9	5	12	14	8	10	23	21	16	12	4	5	2	0
	RHS Median (IQR)	−0.5 (−3.25, 2.25)	6 (4, 8)	4 (−1.5, 5.75)	6 (4.5, 9)	0.5 (−3.5, 3.75)	0.5 (−2.75, 2.75)	−1 (−4, 1.5)	−1 (−4.5, 3.5)	−1 (−3.75, 1)	−3 (−5, 0.25)	−3 (−7, 0)	−9 (−12.5, 0)	−1.5 (−3.25, 1)	−2.5 (−3, −0.5)	−3 (−4.5, −1.5)
	p-value	0.727	0.003	0.344		0.678	0.824	0.549	1	0.03	0.004	0.003	0.118
	HFMSE Median (IQR)	0 (−1.75, 1.75)	3 (1, 4)	3.5 (−2.25, 6)	6 (1, 8)	1 (−0.75, 3)	1.5 (−2.75, 3.75)	−0.5 (−3, 2)	2 (−1.5, 3.5)	−1 (−4, 0.75)	−3 (−6.25, 0)	−4.5 (−9.25, −0.75)	−6 (−10, −2)	−2 (−4, 1)	−2 (−2, −0.5)	−1.5 (−4.25, 1.25)
	p-value	1	0.006	0.344		0.064	0.189	0.754	0.344	0.007	0.001	0.001	0.035
3b	M	1	0	0	0	1	2	0	0	9	7	5	4	15	6	5	6
	N	1	0	0	0	1	1	0	0	3	3	3	2	5	3	3	1
	RHS Median (IQR)						2 (2, 2)			−3 (−8, 0)	1 (−4, 3.5)	3 (−2, 3)	0 (−5.25, 5.75)	−1 (−1.5, 0.5)	1 (−2.75, 4.75)	1 (−1, 5)	0.5 (−0.75, 2.5)
	p-value
	HFMSE Median (IQR)						3 (3, 3)			1 (−2, 2)	1 (−1.5, 2)	1 (−1, 3)	1.5 (−1.25, 3.5)	0 (−1, 1)	0.5 (−2.25, 1.75)	0 (−1, 2)	−0.5 (−1, 3.75)
	p-value