Table 4.
Up to 2-year median change in the RHS and HFMSE cross-tabulated by WHO-derived functional type and age. N: number of participants, M: number of assessments, IQR: inter-quartile range.
| Age | <5 | 5–7 | 8–13 | 14–18 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Functional Type | 6 m | 12 m | 18 m | 24 m | 6 m | 12 m | 18 m | 24 m | 6 m | 12 m | 18 m | 24 m | 6 m | 12 m | 18 m | 24 m | |
| Non-Sitter | M | 3 | 3 | 1 | 0 | 1 | 0 | 1 | 0 | 9 | 10 | 6 | 4 | 1 | 2 | 1 | 0 |
| N | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 0 | 6 | 8 | 4 | 4 | 1 | 2 | 1 | 0 | |
| RHS Median (IQR) | 0 (−0.5, 1.5) | 5 (3.5, 5.5) | 0 (0, 1) | −1 (−1, 0) | −0.5 (−1, 0) | −0.5 (−1, 0.25) | 0 (0, 0) | ||||||||||
| p-value | 0.289 | ||||||||||||||||
| HFMSE Median (IQR) | 1 (0.5, 1.5) | 7 (6, 10) | 0 (0, 1) | −1 (−1, 0) | 0 (0, 0) | 0 (−0.25, 0.25) | 0 (0, 0) | ||||||||||
| p-value | 0.125 | ||||||||||||||||
| Sitter | M | 81 | 61 | 26 | 22 | 38 | 23 | 8 | 9 | 56 | 45 | 29 | 21 | 13 | 9 | 5 | 1 |
| N | 33 | 27 | 17 | 12 | 20 | 15 | 7 | 7 | 28 | 22 | 14 | 13 | 7 | 7 | 4 | 1 | |
| RHS Median (IQR) | 0 (0, 2) | 1 (0, 2) | 2.5 (1, 5) | 1.5 (1, 5.75) | 0 (−1, 0.75) | 0 (−1, 1.5) | −1 (−3.25, 0) | −1 (−2, 0) | −1 (−1.25, 0.25) | −1 (−3, 0) | −2 (−4, 0) | −2 (−5, 0) | 0 (−1, 1) | −1 (−1, 0) | 0 (0, 0) | ||
| p-value | 0.014 | p < 0.001 | p < 0.001 | p < 0.001 | 0.832 | 1 | 0.289 | 0.032 | 0.002 | 0.023 | 0.013 | 1 | 0.453 | ||||
| HFMSE Median (IQR) | 0 (0, 3) | 1 (0, 3) | 3 (0, 6.5) | 2.5 (1, 6) | 0 (−1, 1) | −1 (−2, 1) | −0.5 (−3.25, 0.25) | −2 (−4, 1) | −1 (−3, 0) | −2 (−5, 0) | −4 (−7, −2) | −5 (−8, −1) | 0 (−2, 0) | −1 (−2, 0) | −1 (−1, 0) | ||
| p-value | 0.018 | 0.002 | 0.004 | p < 0.001 | 0.69 | 0.664 | 0.687 | 0.508 | p < 0.001 | p < 0.001 | p < 0.001 | 0.001 | 0.219 | 0.453 | |||
| Transitional Group |
M | 5 | 4 | 2 | 1 | 5 | 6 | 7 | 4 | 10 | 9 | 5 | 2 | 4 | 2 | 0 | 0 |
| N | 2 | 2 | 1 | 1 | 2 | 3 | 3 | 2 | 5 | 7 | 5 | 2 | 3 | 2 | 0 | 0 | |
| RHS Median (IQR) | 1 (0, 2) | −1.5 (−2.25, −0.25) | −1.5 (−1.75, −1.25) | −1 (−3, 0) | −3 (−4.5, −2.25) | −4 (−6, −3) | −7 (−7.5, −6.25) | −2.5 (−3.75, −0.25) | −3 (−6, −2) | −7 (−7, −7) | −6 (−6.5, −5.5) | −0.5 (−2.75, 1) | −3.5 (−3.75, −3.25) | ||||
| p-value | 0.004 | ||||||||||||||||
| HFMSE Median (IQR) | 1 (0, 1) | −1.5 (−3, 0.25) | −2.5 (−2.75, −2.25) | 1 (−4, 3) | −3.5 (−5.5, −1.5) | −5 (−6, −3) | −4 (−5.5, −4) | −2.5 (−4.75, −0.25) | −5 (−9, −3) | −11 (−11, −9) | −8.5 (−10.25, −6.75) | −2 (−3.75, 0.25) | −1 (−1.5, −0.5) | ||||
| p-value | 0.004 | ||||||||||||||||
| Walker | M | 11 | 12 | 10 | 6 | 22 | 19 | 8 | 9 | 43 | 33 | 23 | 16 | 14 | 6 | 5 | 6 |
| N | 7 | 9 | 9 | 5 | 10 | 13 | 5 | 8 | 17 | 14 | 15 | 13 | 4 | 3 | 3 | 1 | |
| RHS Median (IQR) | 0 (−2.5, 3) | 5 (3.5, 8) | 4 (−1.5, 5.75) | 6 (3.75, 7.5) | 1 (−3.5, 3) | 1 (−3, 2.5) | 0.5 (−1, 3.75) | −1 (−3, 4) | −1 (−3, 1) | 0 (−5, 2) | −2 (−5.5, 1.5) | −7.5 (−11.25, 3.25) | −1 (−1.75, 0) | 1 (−2.75, 4.75) | 1 (−1, 5) | 0.5 (−0.75, 2.5) | |
| p-value | 1 | 0.006 | 0.344 | 0.503 | 0.815 | 1 | 0.256 | 0.711 | 0.263 | 0.454 | |||||||
| HFMSE Median (IQR) | 0 (−1.5, 1.5) | 3 (1, 4.5) | 3.5 (−2.25, 6) | 5.5 (0, 8) | 1 (−0.75, 2) | 2 (−2.5, 3.5) | 0.5 (−1, 5.25) | 2 (0, 4) | 0 (−2, 1.5) | −1 (−3, 2) | −1 (−5.5, 1) | −4 (−10, 1.25) | 0 (−0.75, 1) | 0.5 (−2.25, 1.75) | 0 (−1, 2) | −0.5 (−1, 3.75) | |
| p-value | 1 | 0.012 | 0.344 | 0.078 | 0.238 | 0.289 | 0.743 | 0.473 | 0.189 | 0.302 | |||||||