Table 5.
Age | <5 | 5–7 | 8–13 | 14–18 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RHS Baseline Total | 6 m | 12 m | 18 m | 24 m | 6 m | 12 m | 18 m | 24 m | 6 m | 12 m | 18 m | 24 m | 6 m | 12 m | 18 m | 24 m | |
Q1: 0–4 |
M | 17 | 20 | 8 | 9 | 8 | 3 | 1 | 0 | 19 | 19 | 11 | 9 | 8 | 6 | 4 | 1 |
N | 9 | 10 | 6 | 3 | 3 | 1 | 1 | 0 | 11 | 11 | 6 | 8 | 5 | 5 | 3 | 1 | |
RHS Median (IQR) | 1 (0, 2) | 1 (0.75, 1) | 1 (0.75, 3) | 1 (1, 2) | 0 (−1, 0) | 0 (−0.5, 0) | 0 (0, 0.5) | 0 (−1, 0) | 0 (0, 0.5) | 0 (−1, 0) | 0 (−1, 1) | 0 (−0.75, 0) | 0 (0, 0) | ||||
p-value | 0.002 | 0.001 | 0.031 | 1 | 0.388 | ||||||||||||
HFMSE Median (IQR) | 1 (0, 2) | 0.5 (0, 3) | 1 (0, 3.5) | 2 (0, 2) | 0 (−0.25, 0.5) | 1 (1, 1.5) | 0 (0, 0) | −1 (−1, 0) | 0 (−0.5, 0) | 0 (−1, 0) | 0 (0, 0) | 0 (0, 0) | −0.5 (−1, 0) | ||||
p-value | 0.065 | 0.092 | 1 | 0.012 | |||||||||||||
Q2: 5–9 |
M | 39 | 25 | 10 | 5 | 15 | 7 | 2 | 3 | 16 | 12 | 8 | 5 | 1 | 2 | 0 | 0 |
N | 18 | 11 | 6 | 4 | 11 | 5 | 2 | 3 | 10 | 7 | 4 | 2 | 1 | 2 | 0 | 0 | |
RHS Median (IQR) | 0 (0, 2) | 2 (0, 5) | 5.5 (1.5, 7.75) | 8 (7, 9) | 0 (−0.5, 1) | 2 (0, 2) | 1 (0.5, 1.5) | 0 (−0.5, 1) | 0 (−1, 0.25) | −1 (−2, −0.75) | −2 (−3.25, −0.5) | −2 (−3, −1) | 0.5 (−0.25, 1.25) | ||||
p-value | 0.076 | 0.004 | 0.004 | 0.754 | 0.549 | 0.065 | |||||||||||
HFMSE Median (IQR) | 1 (0, 3) | 2 (0, 8) | 6 (1.5, 10.25) | 9 (9, 11) | 0 (−1, 0.5) | 0 (−1.5, 2) | 1 (1, 1) | 1 (−0.5, 2) | −1 (−2.5, 0) | −2.5 (−4, −1) | −4.5 (−6, −4) | −6 (−8, −4) | 0 (−1, 1) | ||||
p-value | 0.043 | 0.004 | 0.002 | 0.754 | 0.065 | 0.012 | |||||||||||
Q3: 10–18 |
M | 27 | 18 | 9 | 7 | 14 | 12 | 6 | 5 | 20 | 16 | 12 | 11 | 1 | 1 | 2 | 0 |
N | 14 | 11 | 8 | 5 | 8 | 10 | 5 | 3 | 11 | 9 | 8 | 7 | 1 | 1 | 2 | 0 | |
RHS Median (IQR) | 0 (−1, 1) | 0 (−1, 1.75) | 2 (−1, 3) | 1 (0.5, 2) | 0 (−0.75, 0) | 0 (−1, 0.25) | −2.5 (−3.75, −0.5) | −1 (−3, −1) | −1 (−2.25, 1) | −2.5 (−5, −0.75) | −3 (−4.75, −0.75) | −5 (−7, −1.5) | −3 (−4.5, −1.5) | ||||
p-value | 0.824 | 1 | 0.508 | 1 | 1 | 0.332 | 0.035 | 0.021 | 0.065 | ||||||||
HFMSE Median (IQR) | 0 (−1.5, 1) | 0.5 (−0.75, 3) | 1 (−3, 3) | 3 (1, 5) | 0 (−2, 1) | −1 (−2.5, 0.25) | −2 (−3.75, −0.25) | −3 (−4, −2) | −1.5 (−3, 0.5) | −3 (−7.25, −1.75) | −4.5 (−9.5, −2.75) | −6 (−11.5, −3.5) | −1.5 (−4.25, 1.25) | ||||
p-value | 0.824 | 0.424 | 0.727 | 1 | 0.227 | 0.064 | 0.007 | 0.012 | 0.065 | ||||||||
Q4: 19–42 |
M | 12 | 14 | 8 | 6 | 10 | 12 | 8 | 6 | 30 | 25 | 15 | 9 | 10 | 6 | 1 | 0 |
N | 7 | 8 | 6 | 4 | 5 | 8 | 4 | 4 | 16 | 16 | 10 | 7 | 4 | 4 | 1 | 0 | |
RHS Median (IQR) | 0.5 (−0.25, 2) | 4 (0.25, 7.5) | 3.5 (−1.25, 6) | 7 (6, 9.5) | −1.5 (−3.75, 0.75) | −2.5 (−5.25, −1.25) | −4 (−6, −2) | −5.5 (−7, −2.5) | −2 (−3.75, −0.25) | −4 (−6, −1) | −6 (−10.5, −4.5) | −9 (−10, −5) | 0.5 (−2.5, 1) | −1.5 (−3, 3) | |||
p-value | 0.508 | 0.092 | 0.727 | 0.146 | 0.004 | 0.001 | 0.001 | 0.18 | |||||||||
HFMSE Median (IQR) | 0.5 (0, 1.25) | 1.5 (−0.5, 3.75) | 3 (−2.25, 6) | 4.5 (0, 7.5) | 1 (−3, 1.75) | −3.5 (−4.25, 1.25) | −4 (−5.5, −2.25) | −4 (−4.75, −4) | −2 (−4, 0) | −5 (−9, −1) | −9 (−11, −5.5) | −6 (−10, −2) | −0.5 (−3.5, 0.75) | −1 (−2, 0.75) | |||
p-value | 0.289 | 0.18 | 0.727 | 0.388 | 0.019 | p < 0.001 | 0.002 | 0.07 | |||||||||
Q5: 43–69 |
M | 5 | 3 | 4 | 2 | 19 | 14 | 7 | 8 | 33 | 25 | 17 | 9 | 12 | 4 | 4 | 6 |
N | 4 | 3 | 4 | 2 | 9 | 9 | 4 | 7 | 12 | 10 | 11 | 9 | 4 | 2 | 2 | 1 | |
RHS Median (IQR) | −1 (−4, 3) | 4 (3, 10.5) | −1 (−6.5, 4.25) | −6 (−10.5, −1.5) | 1 (−3, 2.5) | 1 (−3.5, 2) | 0 (−1, 2) | −1.5 (−3.75, 4.5) | 0 (−2, 2) | 0 (−4, 3) | 0 (−3, 2) | −5 (−15, 3) | −1 (−2, −1) | −2.5 (−3.5, −0.25) | 0 (−1.75, 2) | 0.5 (−0.75, 2.5) | |
p-value | 0.629 | 0.581 | 0.727 | 0.711 | 1 | 0.791 | 1 | ||||||||||
HFMSE Median (IQR) | −1 (−2, −1) | 1 (0.5, 5) | −1 (−6.75, 4.75) | 0 (−4, 4) | 1 (−2, 2.5) | 2.5 (−1.5, 3.75) | 0 (−1, 3.5) | 2 (−0.75, 5) | 0 (−2, 2) | 0 (−2, 3) | −1 (−5, 1) | −3 (−9, 2) | 0 (−2.25, 0.25) | −1.5 (−3.5, 1.25) | −0.5 (−1.5, 1) | −0.5 (−1, 3.75) | |
p-value | 0.238 | 0.267 | 0.453 | 0.851 | 1 | 0.454 | 1 |