Table 2.
Toxicity to normal cells a.
| Compound. | 9j | Selectivity Ratio b | Osimertinib | Selectivity Ratio b |
|---|---|---|---|---|
| LO2 | 23.96 ± 0.03 | 306.1 | 1.72 ± 0.05 | 419.5 |
| HK2 | 25.71 ± 0.08 | 329.6 | 2.13 ± 0.09 | 519.5 |
| HLF | 27.87 ± 0.01 | 357.3 | 3.24 ± 0.08 | 790.2 |
| 293A | 20.003 ± 0.05 | 255.5 | 2.25 ± 0.02 | 548.8 |
| HUVEC | 21.36 ± 0.06 | 273.8 | 4.34 ± 0.01 | 1058.5 |
| H1975 | 0.07829 ± 0.03 | / | 0.0041 ± 0.001 | / |
a Data are presented as the mean ± SE from the dose-response cures of at least three independent experiments. b Selectivity ratio (IC50 human normal cells)/(IC50 H1975).