Table 2.

Influence of pH on liposome stability.

pH Value	Stability Measurements	Testing Time	Active Compounds Encapsulated in Liposomes	Bibliography
3, 4.3, 5, 7	50%, 80%, 80%, 80 retention rates	21 days	Betacyanin	[48]
5.5, 6.0, 6.4, 7.4	Not available	30 min	Doxorubicin hydrochloride	[58]
5.5, 7.4	Cationic liposomes 63.6%, nontargeting liposomes 28.1%, pH-sensitive liposomes 35.6%—release rate in neutral pH 7.4	4 h for acidic conditions, 24 h for alkaline conditions	Afatinib	[46]
2.5, 5.0, 7.4	55%, 43%, 34% encapsulation efficiency post-incubation	6 h	Curcumin	[59]
4.5, 7.4, 10.5	Completely degraded at day 18 acidic, neutral conditions, degraded at day 30 alkaline conditions	30 days	Silver sulfadiazine	[48]
5, 6, 7, 8, 9	>80% acidic conditions retention rate, <50% neutral and alkaline conditions retention rate	30 days	Curcumin	[45]