Table 6.
Recent patent applications and patents on coated liposomes.
| Patent Application/Patent, ID, Title, Year | Material Coating | Effects on Stability |
|---|---|---|
| Ceftazidime combined powder injection and preparation method and product specification thereof, CN111840232A, 2020 | The ceftazidime and chitosan nanoparticles are each coated with vesicles, and the liposomes are then combined to create liposome-mixed nanoparticles | The product purity is high, the selection range is expanded, the side effects are minimal, and the safety is high. The product obtained by the preparation process is of stable quality and good pharmacological effect. |
| Treatment of age-related macular degeneration, US2020262903A1, 2020 | The nanoparticles are coated with a drug targeting the vascular endothelial growth factor receptor (VEGFR), such as anti-VEGFR antibodies, anti-VEGFR aptamers, anti-VEGFR binding peptides | The stability of the nanocomposite at elevated temperatures indicates the successful support of GOF for liposomes |
| A biodegradable nano-theranostic composite and process of preparation thereof, US2020237667A1, 2020 | Graphene oxide (GO) was deposited in the form of a thin film on both the inner and outer surfaces of the liposomes | The stability problem was solved by reinforcing the very fragile lipid membrane-based liposome wall with a dense inclusion of GO. This makes the wall very stable, even at a pH as low as 5 for several hours and at temperature as high as 50 ᵒC |
| DNA brick-assisted liposome sorting US20210267894A1, 2021 |
Liposomes were coated with DNA | The stability of a liposome was improved and more functionalization was possible when a DNA coating was applied. DNA coatings have been useful because nucleases can easily remove them, and they are inert to most biochemical reagents. |
| Liposomes encapsulating anticancer drugs and use thereof in the treatment of malignant tumors US20050100590A1, 2005 |
Liposomes were coated with a lipopeptide consisting of a lipid fragment, an active oligopeptide, and an oligopeptide spacer between the other two fragments | The addition of a negatively charged phospholipid favors the stability of the liposome solution and prevents the spontaneous aggregation of the liposomes |
| Liposome-based mucus-penetrating particles for mucosal delivery US20170281541A1, 2017 |
Liposomes were coated with PEG | PEG was used to increase the stability and solubility of liposomes with drugs, reduce toxicity, and prolong the half-life |
| Method of producing immunoliposomes and compositions thereof US20090232730A1, 2009 |
Liposomes were coated with hyaluronan/hyaluronic acid or other glycosaminoglycans | Hyaluronan/hyaluronic acid provided protection against lyophilization and reconstitution so that only nanoscale liposomes covalently coated with hyaluronan/hyaluronic acid were structurally preserved |
| Liposomal formulations for delivery of nucleic acids US10583084, 2020 |
Liposomes were coated with a glycosaminoglycan (hyaluronic acid) | The coating materials improved the condensation and stability of the liposomes |