Table 6.
Multivariable Hazard Ratio for All-Cause and Cardiovascular Mortality based on the Amount of Sitting Time among Individuals with NAFLD as defined by the Hepatic Steatosis Index.
| Age, Sex-Adjusted Model | Multivariable Model 1 | Multivariable Model 2 | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
| All-cause mortality | ||||||
| Sitting time | ||||||
| Q1 (<4 h) | 1 | <0.001 * | 1 | <0.001 * | 1 | 0.002 * |
| Q2 (4–<6 h) | 0.96 (0.77–1.21) | 0.751 | 0.95 (0.74–1.21) | 0.670 | 0.95 (0.75–1.20) | 0.648 |
| Q3 (6–<8 h) | 1.12 (0.87–1.45) | 0.350 | 1.03 (0.80–1.34) | 0.800 | 1.05 (0.82–1.37) | 0.674 |
| Q4 (≥8 h) | 1.46 (1.23–1.73) | <0.001 | 1.32 (1.10–1.57) | 0.003 | 1.27 (1.06–1.53) | 0.010 |
| Total physical activity (min/week) | ||||||
| 0 | 1 | 0.007 * | 1 | 0.013 * | ||
| 1–149 | 0.61 (0.48–0.78) | <0.001 | 0.63 (0.49–0.80) | <0.001 | ||
| 150–299 | 0.62 (0.44–0.88) | 0.008 | 0.62 (0.43–0.88) | 0.009 | ||
| 300– | 0.73 (0.59–0.90) | 0.004 | 0.75 (0.60–0.92) | 0.008 | ||
| Cardiovascular mortality | ||||||
| Sitting time | ||||||
| Q1 (<4 h) | 1 | <0.001 * | 1 | <0.001 * | 1 | 0.003 * |
| Q2 (4–<6 h) | 1.04 (0.71–1.53) | 0.839 | 1.11 (0.71–1.71) | 0.646 | 1.10 (0.71–1.71) | 0.663 |
| Q3 (6–<8 h) | 1.28 (0.82–2.02) | 0.276 | 1.40 (0.85–2.31) | 0.178 | 1.43 (0.87–2.38) | 0.159 |
| Q4 (≥8 h) | 1.93 (1.36–2.74) | <0.001 | 1.79 (1.23–2.62) | 0.003 | 1.62 (1.10–2.39) | 0.015 |
| Total physical activity (min/week) | ||||||
| 0 | 1 | 0.005 * | 1 | 0.009 * | ||
| 1–149 | 0.58 (0.41–0.83) | 0.003 | 0.63 (0.44–0.90) | 0.013 | ||
| 150–299 | 0.78 (0.49–1.25) | 0.305 | 0.76 (0.47–1.21) | 0.249 | ||
| 300– | 0.59 (0.41–0.83) | 0.003 | 0.60 (0.42–0.86) | 0.006 | ||
The multivariable model 1 was adjusted for age, sex, race/ethnicity, education level, marital status, economic status, smoking status, hypertension, diabetes, total cholesterol, total physical activity, total calorie intake, caffeine consumption, and alcohol consumption using appropriate sampling weights. The multivariable model 2 was adjusted for waist circumference in addition to model 1 using appropriate sampling weights. Abbreviations: NAFLD, nonalcoholic fatty liver disease; OR, odds ratio; CI, confidence interval. Weighted quartile 1, <4 h; quartile 2, ≥4 h to <6 h; quartile 3, ≥6 h to <8 h; quartile 4, ≥8 h. * p-values were analyzed using the test of the trend of hazards.