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. 2023 Mar 10;18(3):e0283024. doi: 10.1371/journal.pone.0283024

Fig 1. Amplification plots for the fluorescent probes representing the four targets ACTB, HbS allele, SMN1, and TREC in samples of four different physiological conditions.

Fig 1

(A) A normal newborn, or screening negative, sample showing a normal amplification of ACTB, SMN1, and TREC, and no amplification of the HbS allele; (B) a reference SCID positive sample showing no TREC amplification; (C) a reference SMA positive sample with no SMN1 amplification; (D) a sample showing HbS amplification indicating the allele presence. The figure was created using R (v. 4.1.2), ggplot2 (v. 3.3.5), dplyr (v. 1.0.7).