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. 2023 Mar 2;12(5):1143. doi: 10.3390/plants12051143

Table 3.

Phenanthroindolizidine alkaloids isolated from the genus Tylophora.

graphic file with name plants-12-01143-i001.jpg
Cpd Trivial Name Plant Name R1 R2 R3 R4 R5 R6 R7 R8 13a Reference
1 Isotylocrebrine T. tanakae
T. indica 		H OCH3 OCH3 H OCH3 OCH3 - - S [73,74,75]
2 Tylophorine T. tanaka,
T. indica
T. crebriflora 		OCH3 OCH3 H H OCH3 OCH3 - - R [73,74,75,76]
3 3-dimethyl isotylocrebrine T.tanakae H OH OCH3 H OCH3 OCH3 - - S [73,74]
4 3-demethyl tylophorinidine T. atrofolliculata H OH H H OH OCH3 - α-OH S [65]
5 3-demethyl-14α-hydroxy isotylocrebrine T. tanakae H OH OCH3 H OCH3 OCH3 - α-OH S [73,74]
6 Isotylocrebrine N-Oxide T. tanakae H OCH3 OCH3 H OCH3 OCH3 O - S [73,74]
7 14α-hydroxy isotylocrebrine N-Oxide T. tanakae H OCH3 OCH3 H OCH3 OCH3 O α-OH S [73,74]
8 3-demethyl-14α-hydroxy isotylocrebrine N-Oxide T. tanakae H OH OCH3 H OCH3 OCH3 O α-OH S [73,74]
9 6-demethyltylocrebrine T. tanakae OCH3 OCH3 H OCH3 OH H - - S [73,74]
10 Tylophorinine T. indica and
T. asthmatica 		H OCH3 H H OCH3 OCH3 - α-OH S [75,77,78]
11 Tylophorinine N-Oxide T. tanakae and
T. atrofolliculata 		H OCH3 H H OCH3 OCH3 O α-OH S [66,73,74]
12 7-demethyltylophorine T. tanakae OCH3 OCH3 H H OCH3 OH - - R [73,74]
13 Tylophorine N-Oxide T. tanakae OCH3 OCH3 H H OCH3 OCH3 O - R [73,74]
14 7-demethyltylophorine-N-Oxide T. tanakae OCH3 OCH3 H H OCH3 OH O - R [73,74]
15 Antofine T. crebriflora OCH3 OCH3 H H OCH3 H - - R [76,79]
16 14α-hydroxy isotylocrebrine T. indica and
T. hirsuta 		H OCH3 OCH3 H OCH3 OCH3 - α-OH S [78,80]
17 4-demethyl isotylocrebrine T. hirsuta H OCH3 OH H OCH3 OCH3 - - S [80]
18 3,6 Didemethyl isotylocrebrine T. tanakae H OH OCH3 H OH OCH3 - - α-OH [73]
19 14-α-Hydroxy 3,6 didemethyl isotylocrebrine T. tanakae H OH OCH3 H OH OCH3 - α-OH α-OH [73]
20 Tylocrebrine T. indica and
T crebriflora 		OCH3 OCH3 H OCH3 OCH3 H - - S [75,76]
21 Tylophorinidine T. indica and
T. atrofolliculata 		H OCH3 H H OH OCH3 - α-OH S [66,75]
22 5-hydroxy-O-methyltylophorinidine T. indica and
T. hirsuta 		H OCH3 H OH OCH3 OCH3 - α-OH S [78,80]
23 Tylophorinidine N-Oxide T. atrofolliculata H OCH3 H H OH OCH3 O α-OH S [66]
24 13 α-Hydroxytylophorine T. hirsuta OCH3 OCH3 H H OCH3 OCH3 - - R [81]
25 6-demethyltylophorine T. indica OCH3 OCH3 H H OH OCH3 - - R [78]
26 4&6-desmethyl isotylocrebrine T. indica H OCH3 OH H OH OCH3 - - S [78]
27 Tyloindicine A T. indica H OCH3 OCH3 OCH3 OCH3 H - - S [78]
28 Tyloindicine D T. indica H OCH3 OCH3 OH OCH3 OCH3 - - S [78]
29 Tyloindicine E T. indica H OCH3 H H OH OCH3 - - S [78]
30 Cryptopleurine T. crebriflora OCH3 OCH3 H H OCH3 H - - R [76]
31 Tylophorinicine T. asthmatica OCH3 OCH3 H H OCH3 OCH3 - β-OH R [82]
graphic file with name plants-12-01143-i002.jpg
Compound Trivial name Plant name R1 R2 R3 Reference
32 Tyloindicine G T. indica OCH3 H OH [83]
33 Tyloindicine H T. indica H OH H [83]
graphic file with name plants-12-01143-i003.jpg
Compound Trivial name Plant name R1 R2 Reference
34 Tylohirsutinine T. hirsuta OCH3 H [84]
35 Tylohirsutinidine T. hirsuta OH αOH [84]
graphic file with name plants-12-01143-i004.jpg
Compound Trivial name Plant name R1 R2 R3 R4 R5 Reference
36 Tyloindicine C T. indica OCH3 OH OH OCH3 - [78]
37 13a-Methyltlohirsutine T. hirsuta OCH3 OCH3 OCH3 OCH3 - [84]
38 13a-Methyltyl-ohirsutinidine T. hirsuta OCH3 OH OCH3 OCH3 α-OH [84]
graphic file with name plants-12-01143-i005.jpg Tylophoridicine D T. atrofolliculata [66]
graphic file with name plants-12-01143-i006.jpg Tyloindane T. indica [83]