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. 2023 Mar 6;28(5):2400. doi: 10.3390/molecules28052400

Figure 2.

Figure 2

Structures of BTK isoforms. pY223 and pY551 are activating phosphorylation sites; C481 is a binding site for BTK inhibitors ibrutinib, spebrutinib, and acalabrutinib [10]. In this review, the term “BTK” refers to the BTK-A isoform unless it is clearly stated otherwise.