Table 1. Top-ranked canonical pathway enrichments.

hDEG	mDEG (HET)	mDEG (KO)
Axonal guidance signaling	Hepatic fibrosis/hepatic stellate cell activation	WNT/β-catenin signaling
GP6 signaling pathway	Tumor microenvironment pathway	Pulmonary fibrosis idiopathic signaling pathway
Renin-angiotensin signaling	Apelin liver signaling pathway	Synaptogenesis signaling pathway
CXCR4 signaling	GP6 signaling pathway	Molecular mechanisms of cancer
Sperm motility	Atherosclerosis signaling	Hepatic fibrosis signaling pathway
P2Y purinergic receptor signaling pathway	Intrinsic prothrombin activation pathway	Axonal guidance signaling
Apelin endothelial signaling pathway	Wound healing signaling pathway	Apelin liver signaling pathway
Dopamine-DARPP32 feedback in cAMP signaling	Pulmonary fibrosis idiopathic signaling pathway	Hepatic fibrosis/hepatic stellate cell activation
α-Adrenergic signaling	Natural killer cell signaling	Regulation of the epithelial mesenchymal transition in development pathway
Synaptic long term depression	Axonal guidance signaling	Pulmonary healing signaling pathway
Gap junction signaling	TR/RXR activation	Osteoarthritis pathway
GPCR-mediated nutrient sensing in enteroendocrine cells	HOTAIR regulatory pathway	Factors promoting cardiogenesis in vertebrates
Natural killer cell signaling	Coronavirus replication pathway	Ovarian cancer signaling
Cholecystokinin/gastrin-mediated signaling	LXR/RXR activation	Mouse embryonic stem cell pluripotency
Role of NFAT in cardiac hypertrophy	FXR/RXR activation	BEX2 signaling pathway
Colorectal cancer metastasis signaling	Osteoarthritis pathway	Iron homeostasis signaling pathway
Thrombin signaling	Iron homeostasis signaling pathway	Intrinsic prothrombin activation pathway
Molecular mechanisms of cancer	NAD signaling pathway	Tumor microenvironment pathway
Endothelin-1 signaling	Remodeling of epithelial adherens junctions	Epithelial adherens junction signaling
GNRH signaling	Phagosome maturation	GP6 signaling pathway