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Evaluation of the inhibitory activity of 3a and 3ae against SARS-CoV-2 Proteases.
| Compound | Structure | SARS-CoV-2 Mpro | SARS-CoV-2 PLpro |
|---|---|---|---|
| 3a |
|
23.39% | n.i. |
| 3ea |
|
23.70% | n.i. |
| Nirmaltrevir |
|
0.003 ± 0.0004 μM a | - |
Notes: % of inhibition of the enzymatic activity at 20 μM; a IC50 was determined for Nirmaltrevir; IC50 value includes standard deviation from two independent experiments, each performed in triplicate; n.i. = no inhibition.
