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. 2001 Nov;69(11):6755–6768. doi: 10.1128/IAI.69.11.6755-6768.2001

FIG. 2.

FIG. 2

Dual effects of IFN-γ on chemokine gene expression in the lungs of C57BL/6 mice after a primary challenge with S. mansoni. Chemokine gene expression was measured by RNase protection assays using RNA from homogenized lung tissue. Chemokine gene expression in the challenged animals was normalized to GAPDH and then divided by the GAPDH-normalized expression for the specific chemokine in the lungs of unmanipulated control mice. Values are the means of samples from four or five mice. (A) Chemokine genes showing diminished expression in IFN-γ+/− (hatched bars) and IFN-γ−/− (open bars) mice compared with that in IFN-γ+/+ (solid bars) mice. (B) Chemokine genes showing enhanced expression in IFN-γ+/− and IFN-γ−/− mice compared with that in IFN-γ+/+ mice. ∗, P < 0.05 by two-tailed Student t test for IFN-γ+/− or IFN-γ−/− mice compared with IFN-γ+/+ mice. Some error bars are too small to be seen.