TABLE 1.
Chemokines analyzed in this studya
| Chemokine | Inducer(s) | Receptor(s) | Principal target(s) |
|---|---|---|---|
| CXC | |||
| KC (CXCL1-3)b | LPS, IL-1, TNF-α, PDGF | CXCR2 | N |
| MIP-2 (CXCL1-3) | LPS, IL-1, TNF-α | CXCR2 | N |
| LIX (CXCL5) | LPS | CXCR2 | N |
| Mig (CXCL9) | IFN-γ | CXCR3 | T, NK, B |
| CRG-2/IP-10 (CXCL10) | IFN-α, -β, -γ, LPS, IL-1, TNF-α | CXCR3 | T, NK, B |
| SDF-1 (CXCL12) | Constitutive | CXCR4 | T, B, D, M, Thy |
| CC | |||
| TCA3/I-309 (CCL1) | LPS, IL-1 | CCR8 | T, M, Thy |
| JE/MCP-1 (CCL2) | LPS, IL-1, TNF-α, IL-4, thrombin, IFN-γ, PDGF, GM-CSF, M-CSF | CCR2 | M, T, NK, Ba, B |
| MIP-1α (CCL3) | LPS, IL-1, TNF-α, IFN-γ, TCR, FCɛR | CCR1, CCR5 | T, M, N, D, E, Ba, NK, B, Thy |
| MIP-1β (CCL4) | LPS, IL-1, TNF-α, TCR, BCR | CCR5 | T, M, D, Thy |
| RANTES (CCL5) | LPS, IL-1, TNF-α, IFN-γ | CCR1, CCR3, CCR5 | T, M, E, Ba, D, NK, N, B, Thy |
| MCP-3/FIC (CCL7) | LPS, IL-1, TNF-α, IFN-γ, PDGF | CCR1, CCR2, CCR3 | M, T, E, Ba, D, NK, Thy |
| MIP-1γ (CCL9) | Constitutive | CCR1 | N, T |
| Eotaxin (CCL11) | IL-1, TNF-α, IL-4, IL-13, IFN-γ | CCR3 | E, Ba, T |
| MCP-5 (CCL12) | LPS, IFN-γ | CCR2 | M, T, B |
| C, lymphotactin (XCL1) | IL-4, TGF-β, TCR | XCR1 | T, NK |
a
Abbreviations: N, neutrophil; B, B lymphocyte; Ba, basophil; D, dendritic cell; E, eosinophil; M, monocyte; NK, natural killer cell; T, T lymphocyte; Thy, thymocyte; BCR, B-cell receptor; TCR, T-cell receptor; FCɛR, immunoglobulin E Fc receptor; PDGF, platelet-derived growth factor; GM-CSF, granulocyte-macrophage colony-stimulating factor.
b
Systematic names are in parentheses beside common names. There are occasional ambiguities in applying the systematic names for human chemokines to their presumed mouse orthologues.