Table 1.
Physical characteristics of R-carvedilol-loaded transfersomes prepared with Tween 80 or sodium cholate and comparison of the ex vivo skin penetration.
| ID * | Ratio | Characterization | 24-h Skin Penetration (%) | |||||
|---|---|---|---|---|---|---|---|---|
| Drug | SPC | Edge Activator | Mean Particle Size (nm) ± SD | PDI ± SD | Zeta Potential (mV) ± SD | % Encapsulation Efficiency | ||
| F1S | 1 | 3 | 0 | 106.15 ± 2.98 | 0.15 ± 0.02 | 8.0 ± 0.67 | 91.6 | 27 |
| F2S | 1 | 3 | 0.25 | 116.73 ± 1.19 | 0.22 ± 0.01 | 16.5 ± 4.72 | 96.5 | 22 |
| F3S | 1 | 3 | 0.5 | 96.50 ± 2.73 | 0.15 ± 0.01 | 8.0 ± 0.98 | 83.6 | 23 |
| F1T | 1 | 3 | 0 | 110.60 ± 0.57 | 0.16 ± 0.02 | 15.4 ± 0.60 | 71.5 | 25 |
| F2T | 1 | 3 | 0.25 | 107.02 ± 1.36 | 0.16 ± 0.02 | 10.34 ± 0.74 | 82.7 | 34 |
| F3T | 1 | 3 | 0.5 | 100.36 ± 0.39 | 0.17 ± 0.02 | 8.16 ± 2.06 | 80.6 | 33 |
*: S: sodium cholate; T: Tween 80.