Figure 7.

Effect of AT-RvD1 on the skin’s natural antioxidant capacity in hairless mice exposed to 4.14 J/cm² UVB radiation. Ferric Reducing Antioxidant Power (FRAP) (A); scavenging capacity of ABTS+ (B); GSH level (C); Nrf2 mRNA expression (D); NQO-1 mRNA expression (E); catalase activity (F); O₂^•− formation measured by NBT reduction to formazan (G); lipid peroxidation (H). Time points for collecting skin samples were: 12 h after UVB exposure for FRAP, ABTS, and GSH; 4 h after exposure for Nrf2 and NQO-1 mRNA expression and lipid peroxidation; and 2 h after exposure for catalase activity and O₂^•− formation. Bars represent means ± SEM. Two separate experiments with five groups of 5 mice per group per experiment were performed. Statistical analysis was performed by one-way ANOVA, followed by Tukey´s post hoc test. * p < 0.05 compared to the nonradiated control group (orange bars); # p < 0.05 compared to the radiated control group (purple bars).