Table 4.
Pharmacokinetic parameters of donepezil and tadalafil in rat plasma after oral administration of a single dose and combined doses (n = 3).
| Parameter | Donepezil (3 mg/kg) | Tadalafil (0.3 mg/kg) | ||
|---|---|---|---|---|
| Alone | with TAD | Alone | with DPZ | |
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |
| Cmax (ng/mL) | 59.776 ± 15.502 | 39.235 ± 16.562 | 17.795 ± 5.998 | 13.750 ± 9.160 |
| AUClast (h·ng/mL) | 129.583 ± 38.090 | 100.500 ± 29.467 | 46.987 ± 24.384 | 34.419 ± 27.372 |
| AUCinf (h·ng/mL) | 133.901 ± 37.878 | 106.379 ± 32.097 | 50.362 ± 23.612 | 38.931 ± 26.821 |
| Tmax (h) | 0.500 ± 0.000 | 0.500 ± 0.000 | 0.500 ± 0.000 | 0.500 ± 0.000 |
| CL/F (L/h) | 2.382 ± 0.759 | 2.980 ± 0.888 | 7.355 ± 4.516 | 11.819 ± 9.852 |
| T1/2 (h) | 2.630 ± 1.302 | 3.793 ± 2.032 | 1.517 ± 0.120 | 1.962 ± 0.212 |
| MRTlast (h) | 2.617 ± 0.923 | 3.735 ± 1.602 | 2.532 ± 0.214 | 3.079 ± 0.444 |
Cmax, peak plasma concentration; AUClast, area under the plasma drug concentration–time curve to the last measurable time; AUCinf, area under the plasma drug concentration–time curve to infinity; Tmax, time to reach peak plasma concentration; CL(inf)/F, apparent systemic clearance; T1/2, terminal elimination half-life; MRTlast, mean residence time from the first observed to last measurable concentration.