Figure 5. Breadth of seroreactive repeat-containing peptides, but not non-repeat peptides, increases with exposure in children.

(a) Breadth of seroreactive non-repeat peptides per person is not significantly different (KS-test p-value >0.05) between the two exposure settings within each age group. (b) Breadth of seroreactive repeat-containing peptides per person is significantly higher (KS-test p-value <0.05) in the high exposure setting than in the moderate exposure setting within the three groups in children, but not adults.

Figure 5—figure supplement 1. Breadth of repeat-containing peptides per person using different repeat index thresholds for categorizing repeat-containing peptides.

Age groups showing significant difference between the two transmission settings are marked by * based on a KS-test p-value <0.05.

Figure 5—figure supplement 2. Seropositivity of individual seroreactive repeat elements increases with exposure in children, but not adults.

Each dot represents a seroreactive repeat element and seropositivity for the repeat element in a given group was calculated as the percent of people in that group enriching for any seroreactive peptide with that repeat element.

Figure 5—figure supplement 3. Controlling for time since infection status, breadth of seroreactive repeat-containing peptides, but not non-repeat peptides, still shows an increase with exposure in children.

Groups showing significant difference between the two transmission settings are marked by * based on a KS-test p-value <0.05.

Figure 5—figure supplement 4. Breadth of seroreactive repeat-containing peptides, but not non-repeat peptides, wanes with increased time since infection in the moderate exposure setting in children.

Groups showing significant differences are marked by * based on a KS-test p-value <0.05.