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. 2023 Mar 1;66(6):3664–3702. doi: 10.1021/acs.jmedchem.2c01229

Figure 1.

Figure 1

Structure of SARS-CoV-2 Mpro (PDB ID 7BUY(12)). The dimeric protein is shown in a cartoon, and one protomer is shown as the gray surface. The three domains are shown in three different colors (domain I in magenta, domain II in cyan, and domain III in blue); the loop connecting domains II and III is in orange. The catalytic site is shown in the inset in the rectangle. Residues are shown as sticks, and subsites S1, S2, S4, and S1′ are indicated over the surface representation of the enzyme.