Skip to main content
. 2023 Mar 1;66(6):3664–3702. doi: 10.1021/acs.jmedchem.2c01229

Figure 10.

Figure 10

(a–c) Representation of the S glycoprotein main domains. (d) Six helix bundle (6HB) in the heptad repeats region forming contacts to S1. (e) 6HB region from the inner region. (f) 6HB full length (PDB ID 7VX1). (g) α-Helix region of S2 glycoprotein [PDB ID 7TGY). (h) Topological representation of a 6HB domain: a–d, amino acid residue interactions hold together the internal HR1 core; d–g and a–e participate in the interhelical knob-in-hole packing. (i, j) HR1 region shows 92.6% homology between SARS-CoV-1 and SARS-CoV-2, while HR2 shows 100% homology; fusion core sequences are evidenced in dark green and amino acid mutations are shown in red.